Following the adventures of the B-movie director, Bill Gabriel Young (Bashar Shbib), Hot Sauce explores the sensation of taste. Suffering from amnesia after being mugged and knocked unconscious, Bill attempts to piece his life together. With the help of his friend Bella (Susan Eyton-Jones), Bill inadvertently discovers that spicy foods help him to regain his early memories bit by bit. His subsequent hot-food binges, however, only serve to reveal that his forgotten life may not be worth remembering. Told with humor and wisdom by Bill's daughter Tanya (Maïa Nadon-Chbib), the story mixes straightforward narrative with documentary-style interviews of people from the filmmaker’s past.

As the different accounts unfold, a common theme emerges : each person casts Bill in an unflattering light - as a shady and insensitive man who has little (if any) talent in his chosen field. In despair over these revelations, Bill is ultimately saved by Tanya, whose open and unqualified acceptance and love convince him that some things in life are definitely worth remembering.